Internal tandem repeats (ITD) within the proximal membrane structural domain of FLT3 represent poor prognostic indicators in AML, and a global non-targeted metabolomic approach has been applied to analyze metabolite differences between sorafenib-sensitive and drug-resistant leukemia cells with FLT3-ITD mutations and found that glycolytic activity was enhanced, accompanied by a disturbed TCA cycle and reduced PPP flux rate, as well as an increased antioxidant capacity of GSH (Fig. 5). Here, FLT3 is linked to acute myeloid leukemia.