GLDC and melanoma: Glycine dehydrogenase has been found to promote GSH production, and knockdown of glycine dehydrogenase induced DNA damage, thereby inhibiting MM cell proliferation.[55] Previous publications have found that exogenous glycine only contributes to purine synthesis in melanoma.[56] In contrast, it has been observed in a recent investigation that MM cells uptake exogenous glycine and further metabolize it into GSH, purines, and serines.[55] In summary, the increased presence of glycine within the BM contributes to the progression of MM by modulating the GSH equilibrium within MM cells.