CD8A and cancer: The R-5-P generated by the PPP increases the rate at which nucleic acids are synthesized in cancer cells.[8] This heightened activation of the PPP in cancer cells serves to mitigate the harmful impact of active reactive oxygen species (ROS) and contributes to the provision of essential materials for DNA replication.[9] The rapid consumption of glucose by cancer cells leads to the creation of a glucose-deficient and lactic acid-abundant environment, compromising the effectiveness of CD8 + T cells and NK cells in fighting tumors,[10] thus promoting tumorigenesis.