Finally, it was discovered that the disruption of mitochondrial metabolic regulation by STAT3 leads to an increased reliance on glycolysis in TKI persistent CML cells, and the targeted inhibition of pyruvate kinase M2, a key glycolysis-regulating enzyme, effectively eliminates these cells. The gene discussed is STAT3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.