Myeloma cells exhibit a notable increase in heat shock protein 60 levels, it inhibits adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), while AMPK inhibits the key enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), which affects FA metabolism coenzyme A by inhibiting malondiyl.[58] Interestingly, experimental studies have found that abnormal glycerophospholipid metabolism induces the secretion of large amounts of IL-6 and growth factors by BM stromal cells, promoting the growth, proliferation and survival of myeloma cells[54] (Fig. 4). Here, PFKFB3 is linked to plasma cell myeloma.