Moreover, increased activity of enzymes participating in the serine biosynthetic process characterizes lymphoma derived from germinal center B-cells, with elevated PHGDH levels correlating with unfavorable outcomes in diffuse large B-cell lymphoma.[26,27] Furthermore, the regulation of various metabolic pathways, such as glycolysis and glutaminolysis, by MYC includes a significant emphasis on the serine synthesis pathway as a crucial hub for cellular proliferation. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.