Cathepsin L2 had a significant promoting effect on skin cancer (OR = 1.312, 95%CI: 1.122-1.534, P < .05), and a promoting tendency for melanoma (OR = 0.899, 95% CI: 0.795–1.018, P = .09) and squamous cell carcinoma (OR = 0.770, 95% CI: 0.583–1.017, P = .06). The gene discussed is CTSV; the disease is squamous cell carcinoma.