Cathepsin H is a type of lysosomal cysteine proteinase with unique amino endopeptidase activity.[19] It has the function of degrading the extracellular matrix and regulating cellular signaling kinases.[17,20] Its primary mechanism may involve promoting cancer invasion and metastasis through processes such as tumor–stroma interaction, extracellular matrix remodeling, and mediating degradation of engulfed matrix proteins within tumor cells.[21]. Here, CTSH is linked to cancer.