TAK1 is involved in various pathophysiological processes, such as cell growth, inflammation, immune response, and oxidative metabolism.[27] TAK1 is involved in the p38 MAPK inflammatory signaling pathway and is involved in NF-κB pathway activity mediated by TNFR, IL-1R, and TLR.[28] Studies have shown that the TAK1-MAPK signaling cascade plays a key role in initiating DKD inflammatory injury. This evidence concerns the gene MAP3K7 and diabetic kidney disease.