Guo X et al showed that Zishen Pill could regulate the p38MAPK signaling pathway in the kidney in DKD and inhibit the production of IL-1β, IL-6, MCP-1, and other inflammatory factors, thereby reducing the renal inflammatory response.[36] Baicalin is an active component of the traditional Chinese medicine Scutellaria baicalensis, which has antibacterial, anti-inflammatory, and antioxidant effects. This evidence concerns the gene CCL2 and diabetic kidney disease.