8-Hydroxy-2-deoxyguanosine is an important biomarker of oxidative stress damage in DNA and inhibits the mRNA expression of NLRP3, Caspase-1 protein, and IL-1β in renal tissue.[50] Therefore, zingiberensis can reduce oxidative stress and the inflammatory response and delay the development of DKD by inhibiting p66Shc activity and the NLRP3 inflammasome. This evidence concerns the gene CASP1 and diabetic kidney disease.