TLR4 and diabetic kidney disease: Oridonin A downregulated the expression of TLR4 and inhibited the NF-κB pathway, which is an important anti-inflammatory mechanism in DKD.[9] Angelica polysaccharide,[10] the main active component of Angelica sinensis, triptolide,[11] the active component of Tripterygium wilfordii, and stilbene glycoside, the active component of Polygonum multiflorum,[12] also have similar effects.