RELA and diabetic kidney disease: Zhang YY et al reported that calycosin could reduce the phosphorylation of IĸBα in mouse renal tubular epithelial cells, downregulate the expression of P65, and weaken renal inflammatory injury in DKD.[18] Gentiopicroside is an active component of the traditional Chinese medicine gentian, which can lower blood lipids and exert anti-inflammatory and antioxidant effects.