Ma et al showed that this recipe could reverse the phosphorylation of IκBα in the kidneys of DKD rats and downregulate P65 expression, thereby inhibiting the production and release of inflammatory cytokines and improving the physiological and biochemical indicators of DKD in rats and the inflammatory state in vivo.[17] Calycosin is an effective component of the traditional Chinese medicine Astragali Radix, which has anti-inflammatory, antioxidant, and antiapoptotic effects. The gene discussed is NFKBIA; the disease is diabetic kidney disease.