TNF and diabetic kidney disease: Zhong Yanhua et al found that Huopu Xialing decoction could inhibit the protein expression of p65, IL-1β, and TNF-α in lipopolysaccharide-induced HBZY-1 rat mesangial cells and the kidneys of DKD rats and reduce the serum inflammatory factors TNF-α and IL-1β and IL-6, suggesting that Huopu Xialing decoction reduced kidney inflammation by inhibiting p65 activity.[20]Toona sinensis is a dried and ripe fruit that has antioxidant, antiatherosclerosis/inflammatory, antidiabetic and other effects, and n-butanol extracts of T sinensis[21] and Liuwei Dihuang Pill[22] also have similar effects.