CCL2 and diabetic kidney disease: Furthermore, baicalin could reduce the expression of inflammatory factors such as IL-1β, IL-6, MCP-1, and TNF-α in renal tissue, improve the pathological state of renal tissue in DKD mice, and relieve renal inflammatory damage.[37] Apigenin[23] and esculin,[33] the active components of the Chinese herbs Coriander and Selaginella, also have similar effects.