NLRP3 and diabetic kidney disease: 8-Hydroxy-2-deoxyguanosine is an important biomarker of oxidative stress damage in DNA and inhibits the mRNA expression of NLRP3, Caspase-1 protein, and IL-1β in renal tissue.[50] Therefore, zingiberensis can reduce oxidative stress and the inflammatory response and delay the development of DKD by inhibiting p66Shc activity and the NLRP3 inflammasome.