NFKB1 and diabetic kidney disease: Han W et al reported that Huangkui capsules could downregulate the expression of IKK in the kidneys of DKD rats and inhibit the phosphorylation of IKK, thereby reducing the degradation of the inhibitory protein IκB, inhibiting the translocation of NF-κB, and antagonizing the inflammatory response in the DKD kidney.[16] The Qi-dan-di-huang Decoction is composed of Astragalus, Salvia miltiorrhiza, R glutinosa, Chinese yam, and licorice.