Exceeding 400 mg of folic acid can completely saturate dihydrofolate reductase, resulting in residual folic acid.[4] This leftover folic acid has the potential to cause cancer.[4] Simultaneously, increased folic acid supplementation may have a tumor-promoting effect on pre-tumor lesions.[34] Our analysis revealed that total folate intake increased the incidence of EC (RR = 1.05, 95% CI: 0.95–1.16), although this association was not statistically significant. This evidence concerns the gene DHFR and cancer.