The results showed that AKT1 mainly involves 12 pathways, with the most significant being ubiquitin-mediated proteolysis (Fig. 10A and D); DRD4 mainly involves 7 pathways, with the most significant being AA metabolism (Fig. 10B and E); KMO mainly involves 4 pathways, with the most significant being Huntington disease (Fig. 10C and F). Here, AKT1 is linked to juvenile Huntington disease.