AKT1 and major depressive disorder: To verify whether the core target genes of XJZT for MDD treatment have changed in patients, we uploaded turquoise module genes, DEG, and potential target genes of XJZT treatment for MDD to the Venny 2.1.0 platform, and obtained 3 intersecting genes, namely AKT1, D(4) dopamine receptor (DRD4), and kynurenine 3-monooxygenase (KMO) (Fig. 9F).