Studies have shown that in head and neck cancer, the P53 mutation rate exceeds 50%.[23] The analysis of mutated genes in synchronous multiple primary carcinoma suggests that P53 and PKB signaling pathways may be involved in the occurrence of synchronous multiple primary carcinoma.[24] Another study indicated that p53 Codon 72 Polymorphism were associated with the risk of second primary tumors in patients with head and neck squamous cell carcinoma. Here, TP53 is linked to head and neck squamous cell carcinoma.