TP53 and breast carcinoma: Based on an analysis of 1191 cancer index patients attending the NCIS Cancer Genetics Clinic, the results of a multigenomic clinical genetic test in Asian patients with multiple primary cancers showed that, in patients with multiple primary cancers, pathogenic variants include BRCA1, BRCA2, mismatch repair genes, APC, ATM, MUTYH, PALB2, RAD50, and TP53 were found.[22] However, in this study, multiple primary tumors mainly involved breast cancer, ovarian cancer, colon cancer, and so on.