PTAFR and Cognitive impairment: Ginkgo biloba is a natural human thrombin inhibitor that can prevent and treat thrombosis and cardiovascular disease.[48] Ginkgolide has the function of regulating neurotransmitter and neuromodulator.[49] In addition, Ginkgolide B, as the most effective platelet-activating factor receptor antagonist, exhibits antithrombotic and anti-inflammatory activities.[50] EGb partially improves memory and cognitive impairment caused by AD by modulating synaptic plasticity.