IL1B and Intervertebral disk degeneration: Among them, IL-1, IL-6, IL-8 and TNF-α are considered as proinflammatory factors, while IL-2, IL-4 and IL-10 are considered as anti-inflammatory factors.[14] The inflammatory factors that are closely related to intervertebral disc degeneration are mainly IL-1α, IL-1β, IL-6, IL-8 and TNF-α.[15,16]