CCR8 and cancer: A decade ago, researchers established that PA could reduce the expression of downstream protein kinase B (AKT), weaken cancer cells’ activity, and limit cancer growth by suppressing the phospholipase A2 family of arachidonic acid-generating enzymes.[15,16] Hong et al[17] demonstrated that PA inhibited PITPNM3 phosphorylation to reduce p-PITPNM3 and chemokine (C-C motif) receptor 8 binding, which inhibited BC spread.