BCL2 and cancer: Bcl-2 and B-cell lymphoma-extra large (Bcl-XL) were also negatively regulated by Bax, BAK, BIM, BH3-interacting domain death agonist, and PUMA.[27] As a result of treating various types of cancer (Table 1), PA activated pro-apoptotic proteins (Cyt-c, Bax, caspase-3, -8, and -9) and inhibited antiapoptotic proteins (Bcl-2 and Bcl-XL).[21,31,33,36]