STAT3 activation promoted cancer cells to encode Bcl-2, inhibited the expression of Bax/BAK, and increased the expression of cell cycle and angiogenesis factor regulator genes.[50,51] Sun and Xia[29] found that PA inhibited JAK2/STAT3 signaling, reduced Bcl-2 expression, and promoted apoptosis of cancer cells. Here, BAK1 is linked to cancer.