The Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway had been confirmed to regulate cell processes in a variety of cancer cells.[47–49] As the cancer microenvironment accumulates cytokines IL-6 and IL-10, STAT3 is activated by the continuous activation of cytokine receptors (vascular endothelial growth factor receptor/epidermal growth factor receptor) or nonreceptor tyrosine kinases (JAKs, Src, and Abl). This evidence concerns the gene IL10 and cancer.