EPCAM and cancer: It’s clear that EpCAM facilitates the proliferation and metastasis of numerous types of cancers [23, 25] It was observed that EpCAM-CAR T-cells can eradicate EpCAM+ cancer cell lines and release remarkable levels of interferon- α (INF-α) and interferon- γ (INF-γ) in vitro and inhibited cancer growth in colon animal models in vivo [25].