In the treatment of hepatocellular carcinoma, curcumin reduced the level of alpha-fetoprotein in liver tissue, increased the number of immune cells (e.g., NK cells), and inhibited EMT by regulating IL-6/JAK/STAT3 and IL-1β/NF-κB pathways, thereby protecting against the progression of hepatocellular carcinoma (Man et al. 2020). Here, IL1B is linked to hepatocellular carcinoma.