While the common gene expression patterns between HF models related to TGFβ and Smad3 activity together with upregulation of ECM genes, distinctive HFpEF fibroblast activation patterns included upregulation of Angptl4 and other markers of metabolic stress, basement membrane genes, and activation of proinflammatory pathways and TFs. Here, ANGPTL4 is linked to hydrops fetalis.