ANGPTL4 and obesity due to melanocortin 4 receptor deficiency: Elevated ANGPTL4 levels have been reported in the plasma of both HFpEF and HFrEF patients [57], suggesting that more phenotypically fine-grained plasma studies are needed to dissect the association of ANGPTL4 with the HF phenotypes and relevant comorbidities like obesity and atherosclerosis.