PDHX and hepatocellular carcinoma: We and others have demonstrated that p300 is highly expressed in HCC (Fig. S2C) (Li et al, 2011; Yokomizo et al, 2011), additionally, the levels of acetyl-coA in tumors are high (Guertin and Wellen, 2023), which leads to high basal levels of PDHX K488 acetylation.