Previous studies examining the function of PDC focused on the regulation of PDHA(E1α) by kinases and phosphatases (Cai et al., 2020; Fan et al., 2014; Nie et al., 2020), leading to the use of PDK inhibitor DCA to promote PDC activity therapeutically in cancer patients (Haugrud et al., 2014; Shen et al., 2015). Here, PDC is linked to cancer.