NOTCH1 and B-cell chronic lymphocytic leukemia: In the context of our prospective O-CLL1 study, we herein explored the predictive role of 513 miRNAs on TTFT by (i) incorporating significant miRNAs into a basic prognostic model including IGHV mutational status, del11q and del17p, beta-2-microglobulin (B2M), NOTCH1 mutation, and Rai stage, which are known to predict TTFT in CLL [51,52,53,54], and (ii) analyzing their potential association with 50 genes involved in TTFT that we previously identified by an artificial intelligence (AI)-based model.