In addition, miRNAs may contribute to the deregulation of apoptosis [31,32,33], BCR signaling [34,35,36], or metabolism [37] in CLL cells, and treatment of CLL patients with chemotherapy or BCR inhibitors was shown to affect the expression of miRNAs involved in these processes [38,39,40]. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.