Intravenous transplantation of BM-MSCs in a STZ-DM mice model significantly reduced the astrogliosis and microgliosis observed in the spinal region, along with a decrease in inflammation, as evidenced by increased IL-10 and transforming growth factor (TGF)-β and reduced IL-1β and TNF-α levels [36]. The gene discussed is IL1B; the disease is diabetes mellitus.