The overlapping interacting proteins of ITIH4 were ALB, TG, HSPA1B, PGK1, ACTBL2, ACTG1, VTN, FN1, CXCR4, CXCR5, CCR5, CCL4, SDC3, SCD5, CR2, CD8A, CD4, and CD209, which were found to have a link with RA. This evidence concerns the gene ACTG1 and rheumatoid arthritis.