Increases in CatS expression have been reported in oral cancer [4], prostate cancer [5], lung cancer [6], diabetes mellitus [7], atherosclerosis [8], hypertension [9], myocardial infarction [10], obesity [11], autoimmune diseases [12,13], and many more. The gene discussed is PIMREG; the disease is obesity due to melanocortin 4 receptor deficiency.