CD274 and renal cell carcinoma: Finally, in the IMmotion151 study, despite its negative outcome, it was observed that patients in the sunitinib group with PD-L1 expression had a reduced PFS, particularly when PD-L1 expression was associated with the sarcomatoid features, with a median of 8.4 months in the ITT population compared to 5.6 months in the cohort with PD-L1-positive sarcomatoid RCC [16].