Notably, 2B4, a member of the signaling lymphocytic activation molecule (SLAM) family, transduces activation signals through the SLAM-associated protein (SAP), which results in NK cell activation, enhancing cytotoxicity and interferon-gamma production, which improves anti-tumor efficacy compared to 4-1BB-CD3ζ CAR-NK constructs [32]. The gene discussed is SH2D1A; the disease is neoplasm.