SETDB1 and neoplasm: Interference with PHF8 can cause the degradation of intracellular methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1), leading to the transcriptional activation of H3K9me3-modified retrotransposons, which will induce an intracellular antiviral response and an anti-tumor immune response [26].