MAP2K1 and acute lymphoblastic leukemia: In addition, PHF8 directly binds to the MEK1 promoter, leading to MEK1 transcriptional upregulation and the activation of the MER/ERK signaling pathway that promotes the proliferation of acute lymphoblastic leukemia, with the use of pathway inhibitor PD184352 potentiating the inhibitory effect of PHF8 gene knockout [84].