Genes associated with human myopathies extend well beyond TPM2 and encode sarcomere components, including actin (ACTA1) and myosin heavy chain (MYH2, MYH7); regulators of sarcomere assembly and stability, including nebulin (NEB) and titin (TTN); and regulators of contractility, including ryanodine receptors (RYR1, RYR3). This evidence concerns the gene NEB and myopathy.