The investigation of regulatory disorders caused by altered EV secretion, modifying the regulation of genes and protein expression and several signaling pathways such as wingless signaling pathway (WNT), transforming growth factor beta (TGF-β), neurotrophins, insulin signaling pathways, mitogen-activated protein kinase (MAPK), epidermal growth factor receptor (ErbB) pathways and pathways associated with ubiquitin, could offer insights into implantation failure in women with reproductive diseases [159,160]. The gene discussed is EGFR; the disease is reproductive system disorder.