For example, inA. fumigatus and AD, studies suggest that specific IgE-mediated activation is induced not by multiple allergens and not by a few major allergens, as is the case with asthma and rhinitis.12,13 Another problem presented by the diagnosis of allergic diseases associated withA. fumigatus is the lack of standardized allergens for preparation of molecular component tests. This evidence concerns the gene IGHE and Alzheimer disease.