IGHE and Alzheimer disease: Over the past 30 years, the prevalence of AD has shown a notable rise, affecting between 5% and 20% of the child population and approximately 7% of adults in industrialized countries.1,2 The pathogenesis of AD is not completely clear; however, allergens can activate an intense Th2 response.3 While IgE-mediated pathways are prominent in atopic dermatitis, non-IgE mechanisms also play a crucial role, particularly in contact dermatitis and in some cases of atopic dermatitis where patients do not exhibit elevated IgE levels.