Helicobacter pylori infection can increase chronic inflammation with a decreased level of anti‐inflammatory factors such as IL‐6 and TNF‐a36; in addition, Helicobacter pylori has two variants ACE1 and ACE2 that express ACE2 in the effect of contact with the epithelial cells of the stomach increases and causes the regulation of the patient's immune system to be disturbed37; on the other hand, COVID‐19, like Sars, uses Angiotensin‐Converting Enzyme‐2 to enter the cell as a cell receptor.38 The gene discussed is ACE; the disease is COVID-19.