RUNX1 and acute myeloid leukemia: The International Consensus Classification and the updated World Health Organization (WHO) classification emphasize genetic aberrations in defining AML subtypes, with key abnormalities including translocations like t(8;21 (q22;q22.1)/RUNX1::RUNX1T1 and inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/CBFB::MYH11 [5,6].