AML: acute myeloid leukemia; ALL: acute lymphoblastic leukemia; MRD: minimal residual disease; NPM1: nucleophosmin 1; FLT3: Fms-like tyrosine kinase-3; CNS: central nervous system; SCT: Stem cell transplantation; CR: complete remission. The gene discussed is FLT3; the disease is acute lymphoblastic leukemia.