In MTHFR polymorphisms, it has been observed that the MTHFR mutation is associated not only with osteoporosis and fractures but also with a range of other conditions, including thromboembolic events, malignancies, psychiatric disorders, hypertension, cognitive impairment and Alzheimer's disease, etc9-12, 20. Here, MTHFR is linked to early-onset autosomal dominant Alzheimer disease.