TLR7 and Autoimmunity: Prior studies by our group have demonstrated that Tlr7 agonism accelerates disease in female pSD mice and drives expansion of age-associated B cells (ABCs), a B cell subset that mediates autoimmunity (Punnanitinont et al., 2022; Punnanitinont et al., 2024; Cancro, 2020; Phalke et al., 2022).