EPCAM and cancer: For instance, BiTE encoding mRNA with 1-methylpseudouridine (RiboMAB) simultaneously targets CD3 and one of three TAAs: claudin-6 (CLDN6), claudin 18.2 (CLDN18.2), or epithelial cell adhesion molecule (EpCAM), which has been shown to induce effective T-cell activation and targeted cancer cell lysis at low concentrations 26.