To determine the change in autophagy and SNX3-retromer levels in other cell types after honokiol treatment, we conducted western blot assays on NCM460 (normal intestinal), HT29 (KRAS wild-type colorectal cancer), SW480 (KRASG12V mutant colorectal cancer), SW1990 (KRASG12D mutant pancreatic cancer), and H1975 (EGFRL858R/T790M mutant lung cancer) cells. This evidence concerns the gene KRAS and familial pancreatic carcinoma.