SLC1A2 and epilepsy: Although conditional EAAT2 knockout in the astrocytes of mice increases extracellular glutamate levels 47, suggesting that EAAT2 plays a role in controlling glutamate concentration, other studies have reported that overexpressing EAAT2 in epilepsy mice only reduces glutamate levels during the acute phase (within 3 days of modeling), not in the chronic phase (28 days post-modeling) 48.