In contrast to the APECED serum (containing high concentrations of IFNα neutralizing autoantibodies), we could not detect an inhibitory effect of serum from TB (n = 6) or sarcoidosis (n = 6) with high anti-IFNα2 reactivity on IFNα induced STAT1 phosphorylation in THP-1 cells (Supplementary Fig. 3A). Here, IFNA2 is linked to sarcoidosis.