Genes that have known associations with AD include CHGB (Lechner et al., 2004; Quinn et al., 2020; Marksteiner et al., 2002; Willis et al., 2008), GLCE (Perez-Lopez et al., 2021; Ozsan McMillan et al., 2023; Liachko et al., 2019; Schultheis et al., 2021), CDK5RAP1 (Esteras et al., 2012) and the gene it regulates, CDK5 (Liu et al., 2016; Maccioni et al., 2001; Shukla et al., 2012; Tsai et al., 2004; Cruz and Tsai, 2004; Monaco III, 2005; Maitra and Vincent, 2022; Nikhil et al., 2019; Lau and Ahlijanian, 2003; Pei et al., 1998), and POLR2A (Dickson et al., 2021). This evidence concerns the gene CDK5 and Alzheimer disease.