CDK5 regulatory subunit-associated protein 1 (CDK5RAP1) is involved in checkpoint and arrest in the cell cycle as it inhibits CDK5, a protein with strong implications for AD progression (Liu et al., 2016; Maccioni et al., 2001; Shukla et al., 2012; Tsai et al., 2004; Cruz and Tsai, 2004; Monaco III, 2005; Maitra and Vincent, 2022; Nikhil et al., 2019; Lau and Ahlijanian, 2003; Pei et al., 1998). This evidence concerns the gene CDK5RAP1 and Alzheimer disease.