Molecular analysis of tumor tissue and a peripheral blood sample using OPXv7 identified a heterozygous germline pathogenic gain-of-function variant in PTPN11 p.Asn58Lys (classified as pathogenic in ClinVar, variation ID: 40488) and a germline heterozygous EGFR nonsense variant p.Arg531Ter along with a somatic FGFR1 p.Asn546Lys alteration (Table 2). This evidence concerns the gene FGFR1 and neoplasm.