WFDC2 and obesity due to melanocortin 4 receptor deficiency: In univariate analysis, we found the predictive factors for coexisting EC were older age (OR = 1.05; 95% CI = 1.02–1.09; P = 0.001), obesity (OR = 2.00; 95% CI = 1.18–3.39; P = 0.010), higher level of serum HE4 (OR = 3.94; 95% CI = 2.24–6.95; P< 0.001), and longer postmenopausal time (postmenopausal time< 5 years vs. premenopausal status: OR = 2.61, 95% CI = 1.29–5.28, P = 0.007; postmenopausal time ≥ 5 years vs. premenopausal status: OR = 7.53, 95% CI = 3.39–16.71, P< 0.001).