Furthermore, I/R‐ and cisplatin‐stimulated AKI in mice were exacerbated in proximal‐tubule‐specific PRDM16 knockout (PRDM16‐PT‐KO) mice, while attenuated in proximal‐tubule‐specific PRDM16 knockin (PRDM16‐PT‐KI) mice. Here, PRDM16 is linked to acute kidney injury.