F2 and acute kidney injury: Furthermore, I/R‐ and cisplatin‐stimulated AKI in mice were exacerbated in proximal‐tubule‐specific PRDM16 knockout (PRDM16‐PT‐KO) mice, while attenuated in proximal‐tubule‐specific PRDM16 knockin (PRDM16‐PT‐KI) mice.