Knockdown of S100A6 obviously exacerbated AKI induced by both I/R and cisplatin, as evidenced by increased BUN and Cr levels (Figures S9A–C and S10A,B), along with RTD (Figures S9D,G and S10C,F) and renal tubular cell apoptosis (Figures S9E,H and S10D,G). This evidence concerns the gene S100A6 and acute kidney injury.