Furthermore, formononetin reduced the progression of I/R‐ and cisplatin‐triggered AKI in PRDM16‐PT‐WT mice, but not in PRDM16‐PT‐KO mice, via regulation of the S100A6/PKC‐η/ROS/p38MAPK and the JNK axes (Figures S16 and S17). Here, MAPK8 is linked to acute kidney injury.