When we compared the D-dimer, fibrinogen levels, and ACE2 G8790A gene polymorphism, D-dimer and fibrinogen levels of the COVID-19 patients without lung involvement with GG genotype were 988.3 ± 941.2 μg/mL and 455.9 ± 139.1 mg/dL, with GA genotype were 534.5 ± 386.6 μg/mL and 384.2 ± 97.9 mg/dL, and with AA genotype were 513.1 ± 376.7 μg/mL, 379.2 ± 59.0 mg/dL, respectively. The gene discussed is ACE2; the disease is COVID-19.