In a study with colorectal cancer cells, HO-1 expression decreased the cell-mediated cytotoxicity by lowering the expression of ICAM-1 and CXCL10, which suppressed the adhesion of peripheral blood mononuclear lymphocytes to the colorectal carcinoma cells and the recruitment of T effector cells which regulate anti-tumor immunity 187. This evidence concerns the gene HMOX1 and colorectal cancer.