Overexpression of Sestrin2 activates AMPK, which inhibits the phosphorylation of mTORC and the proliferating cell nuclear antigen, resulting in the induction of apoptosis (Caspase-3, -7, and -9) in colorectal cancer cell lines SW620 and LoVo, as well as in an in vivo mouse model 141. The gene discussed is PRKAA1; the disease is colorectal cancer.