Curcumin can help promote the excretion of excess Cu2+ in a concentration-dependent manner, diminish the accumulation of Cu2+, reduce intracellular Cu2+ content in hepatolenticular degeneration (HLD) hepatocytes, and protect the copper-injured HLD model from oxidative stress based on the Nrf2/HO-1/GPX4 signaling pathway to achieve a protective function in normal rat hepatocytes119. This evidence concerns the gene HMOX1 and leukodystrophy.