GPX4 and inflammatory bowel disease: Encapsulation of cerium oxide nanoparticles (CeO2) and curcumin in mannose-modified chitosan (MCS) enhanced the therapeutic efficacy of inflammatory bowel disease (IBD), on the one hand, by increasing the expression of GSH and GPX4 to protect intestinal cells from ferroptosis, and, on the other hand, it could leverage the targeting of macrophages to minimize effects beyond the site of colonic inflammation125.