RUNX1 and digestive system neoplasm: Furthermore, since the liver is the most common metastatic site for CRC 33, and given the aforementioned findings indicating that hepatocellular carcinoma was also a type of digestive tumor characterized by abnormal upregulation of RUNX1 expression, we became intrigued about the alterations in RUNX1 expression observed in hepatocellular carcinoma cell lines.