In addition, ILC can also affect signaling pathways such as IL-33/ST2, AREG-EGFR, AKT, STAT-3, etc. Moreover, ILC recruits, polarizes and functionally affects CD8+ T cells, Tregs, MDSC, neutrophils, and macrophages, which helps to shape the tumor immune microenvironment. This evidence concerns the gene AKT1 and neoplasm.