Moreover, NK cells and recombinant IL-15 (rIL-15) can inhibit fibrosis in chronic pancreatitis, a key target for pancreatitis and pancreatic cancer treatment, by inhibiting the atrophy of alveolar cells, preventing tissue collagen accumulation around blood vessels, and regulating pro-fibrotic genes 36, 151. This evidence concerns the gene IL15 and pancreatic neoplasm.