Mechanistically, high ferritin light chain (FTL) in TAMs promotes M2 polarization through facilitating ferroptosis by inhibiting the expression of iPLA2β, which expedites tumor progression through inducing an immunosuppressive microenvironment, promoting tolerance to anti-PD-L1 therapy, as well as facilitating glioma angiogenesis177. The gene discussed is CD274; the disease is neoplasm.