To further elucidate the underlying molecular mechanism by which NOP2 exerts tumor-promoting effects in ccRCC, we performed RNA sequencing (RNA-seq) and m5C bisulfite sequencing (Bis-seq) on 786-O cells with NOP2 knocked down (siNOP2) and control cells (siNC). The gene discussed is NOP2; the disease is nonpapillary renal cell carcinoma.