As expected, the expression of APOL1 was knocked down in NOP2-overexpressed 786-O and 769-P cells using specific siRNAs, which moderately suppressed NOP2-induced ccRCC cell proliferation (Fig. 6F; Supplementary Fig. S4D), colony formation (Supplementary Fig. S4E), migration, and invasion abilities (Fig. 6G; Supplementary Fig. S4F). The gene discussed is NOP2; the disease is nonpapillary renal cell carcinoma.