Furthermore, animal model experiments were conducted to verify the roles of NOP2 in vivo, which showed that NOP2 depletion suppressed tumor growth, as reflected by the tumor size and weight compared with those of tumors formed from wild-type (Wt) 786-O cells, whereas overexpression of NOP2 significantly promoted tumor growth in nude mice (Fig. 2I-K). Here, NOP2 is linked to neoplasm.