ESM1 and gastric cancer: Conversely, treatment with the Akt-specific inhibitor, MK-2206, markedly reversed ESM1-induced increases in ANGPT2, p-Akt, p-STAT3, Snail, and Slug (Figure 4E), as well as the migratory ability (Figure 4F) and anoikis resistance (Figure S4E) in GC cells.