ABCC2 and non-small cell lung carcinoma: Thus, to determine which m6A reader is essential for ABCC2 expression, we knocked down each of eight genes that have been identified as m6A reader in A549 and NCI-H460 cells, and strikingly found that knockdown of YTHDF1 substantially decreased mRNA expression of ABCC2 in both NSCLC cell lines (Supplementary Figure S12A).