These results suggest that YTHDF1 may play a potential oncogenic role in lung cancer and function as a m6A reader protein of ABCC2. To determine whether YTHDF1 can regulate mRNA stability of ABCC2, we first demonstrated the binding of YTHDF1 in ABCC2 mRNA by RIP and agarose electrophoresis assay (Fig. 6A). The gene discussed is ABCC2; the disease is lung cancer.