Thus, to determine which m6A reader is essential for ABCC2 expression, we knocked down each of eight genes that have been identified as m6A reader in A549 and NCI-H460 cells, and strikingly found that knockdown of YTHDF1 substantially decreased mRNA expression of ABCC2 in both NSCLC cell lines (Supplementary Figure S12A). This evidence concerns the gene YTHDF1 and non-small cell lung carcinoma.