YTHDF1 and cancer: Briefly, ABCC2 mRNA expression was up-regulated in NSCLC cells upon PTX or CBP treatment, and further modified by METTL3-mediated m6A. Moreover, YTHDF1 bond with and stabilized m6A modified mRNA of ABCC2 to up-regulate ABCC2 in the cytomembrane and promote the efflux of anti-cancer drugs such as PTX and CBP, thus leading to chemotherapy resistance.