To determine whether METTL3 inhibition can sensitize NSCLC cells to PTX or CBP by regulating ABCC2 expression in cytomembrane, we treated A549 and NCI-H460 cells with STM2457 or knocked down METTL3 in these cells, and evaluated their effect on the expression of ABCC2 by qRT-PCR, western blotting, flow cytometry and immunofluorescence assays. Here, METTL3 is linked to non-small cell lung carcinoma.