We analyzed the mRNA stability of PTGR1 in HCC cells with or without NUCB2 depletion to explore the molecular mechanism by which NUCB2 upregulated PTGR1 RNA and protein levels and found that inhibition of NUCB2 showed no effect on the mRNA stability of PTGR1in SNU449 and Huh-7 cells (Figures 4G-H). The gene discussed is NUCB2; the disease is hepatocellular carcinoma.