SIX4 and neoplasm: Multivariate Cox regression analysis showed that tumor recurrence (P = 0.012 HR = 2.571 95%CI = 1.231-5.371) and the expression of SIX4 (P = 0.029 HR = 2.445 95%CI = 1.098-5.445) were identified as the independent risk factors (Figure 3F).