Comparative analysis of hub genes to identify genetic mutations in ovarian cancer revealed that the TCP1 gene has a mutational burden in 3% of cases, RPS6 in 2.6%, RPL2 in 1.2%, CTNNB1 in 1%, RPL5 in 1.5%, RPL7 in 4%, HSPA4 in 1.2%, CCT5 in 7%, RPS2 in 1.4%, and CALM3 in 1.4% of cases of ovarian cancer. This evidence concerns the gene RPS2 and ovarian cancer.