PLCB3 and Autoimmunity: Five significant SNPs (OR >1) were identified, namely: (1) rs10774624, a single nucleotide variation (SNV) of LINC02356; (2) rs2476601, a SNV of PTPN22, linked to autoimmune conditions; (3) rs12421615, a SNV of PLCB3, encoding phospholipase C beta-3; (4) rs1043101, a SNV of SLC1A2, involved in glutamate clearance; and (5) rs2111485, a SNV of IFIH1, involved in innate immunity (Fig 1).