CD86 and neoplasm: Co-receptors CD80 (B7-1) and CD86 (B7-2) that are expressed on antigen-presenting cells (APCs) are also receptors of AdV3, allowing for the possibility of AdV3s to infect APCs and provide the tumor-associated antigens directly (if modified to do so) (Zhang and Bergelson, 2005; Zhao et al., 2021).