Uncovering the precise role of lncRNA CADM2-AS1/miR-5047/NOTCH4 regulatory axis in GC metastasis will not only increase our knowledge of noncoding RNAs-regulated therapeutic effect in cancer metastasis and the underlying regulatory mechanism, but also help develop more efficient strategies to reduce the incidence of GC metastasis. Here, CADM2 is linked to gastric cancer.